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EXERCISE IS STILL THE BASELINE

The Diary of a CEO with Steven Bartlett ยท 17/09/2026 ยท added by men35 desk

EXERCISE IS STILL THE BASELINE

Longevity science may eventually produce sophisticated therapies. But for men over 35, one of the strongest tools is still remarkably ordinary: regular physical activity. ๐—ž๐—˜๐—ฌ ๐—•๐—˜๐—ก๐—˜๐—™๐—œ๐—ง๐—ฆ Explains why exercise remains central to longevity Connects strength with long-term health Highlights the value of combining aerobic and resistance training Puts experimental longevity science into practical perspective ๐—ง๐—›๐—˜ ๐—Ÿ๐—ข๐—ก๐—š๐—˜๐—ฉ๐—œ๐—ง๐—ฌ ๐—ง๐—ข๐—ข๐—Ÿ ๐—ฌ๐—ข๐—จ ๐—”๐—Ÿ๐—ฅ๐—˜๐—”๐——๐—ฌ ๐—›๐—”๐—ฉ๐—˜ It is easy to become fascinated by NAD+, cellular reprogramming and biological-age clocks. But exercise has something those technologies do not yet have: Decades of human evidence. Large observational datasets and meta-analyses consistently associate physical activity with lower risks of premature death and major chronic disease. ๐—ฆ๐—ง๐—ฅ๐—˜๐—ก๐—š๐—ง๐—› ๐— ๐—”๐—ง๐—ง๐—˜๐—ฅ๐—ฆ For men 35+, resistance training deserves particular attention. A systematic review and meta-analysis found that muscle-strengthening activity was associated with lower risks of all-cause mortality, cardiovascular disease, cancer and diabetes. The analysis found associations with roughly 10โ€“17% lower risk across several major outcomes. Another meta-analysis found resistance training was associated with lower all-cause mortality, with additional benefit when combined with aerobic exercise. ๐—ง๐—›๐—œ๐—ก๐—ž ๐—œ๐—ก ๐—–๐—”๐—ฃ๐—”๐—–๐—œ๐—ง๐—ฌ, ๐—ก๐—ข๐—ง ๐—๐—จ๐—ฆ๐—ง ๐—–๐—”๐—Ÿ๐—ข๐—ฅ๐—œ๐—˜๐—ฆ Exercise isn't simply about burning calories. It helps maintain muscle, strength, cardiovascular fitness and physical independence. Those become increasingly valuable as the decades accumulate. ๐—ง๐—›๐—˜ ๐— ๐—˜๐—ก๐Ÿฏ๐Ÿฑ ๐—™๐—ฅ๐—”๐— ๐—˜๐—ช๐—ข๐—ฅ๐—ž You don't need to train like an athlete. A sensible foundation is: Resistance training to preserve muscle and strength. Aerobic activity to maintain cardiovascular fitness. Daily movement to avoid turning the rest of the day sedentary. Consistency matters more than chasing the perfect program. ๐— ๐—˜๐—ก๐Ÿฏ๐Ÿฑ ๐—ง๐—”๐—ž๐—˜๐—”๐—ช๐—”๐—ฌ The future of longevity medicine may be extraordinary. But you don't need to wait for it. Build the biological foundation now. ๐—ง๐—›๐—˜ ๐—•๐—ข๐—ง๐—ง๐—ข๐—  ๐—Ÿ๐—œ๐—ก๐—˜ For men over 35, exercise remains one of the most evidence-backed investments in long-term health. Move better. Stay strong. Keep going.

David A. Sinclair, A.O., Ph.D.

Professor of Genetics, Harvard Medical School ยท Aging biology, NAD+ metabolism, epigenetics and longevity

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For informational purposes only. This is not medical advice โ€” consult a doctor before changing medication, supplements or training.