Health ยท Expert
EXERCISE IS STILL THE BASELINE
The Diary of a CEO with Steven Bartlett ยท 17/09/2026 ยท added by men35 desk

Longevity science may eventually produce sophisticated therapies. But for men over 35, one of the strongest tools is still remarkably ordinary: regular physical activity. ๐๐๐ฌ ๐๐๐ก๐๐๐๐ง๐ฆ Explains why exercise remains central to longevity Connects strength with long-term health Highlights the value of combining aerobic and resistance training Puts experimental longevity science into practical perspective ๐ง๐๐ ๐๐ข๐ก๐๐๐ฉ๐๐ง๐ฌ ๐ง๐ข๐ข๐ ๐ฌ๐ข๐จ ๐๐๐ฅ๐๐๐๐ฌ ๐๐๐ฉ๐ It is easy to become fascinated by NAD+, cellular reprogramming and biological-age clocks. But exercise has something those technologies do not yet have: Decades of human evidence. Large observational datasets and meta-analyses consistently associate physical activity with lower risks of premature death and major chronic disease. ๐ฆ๐ง๐ฅ๐๐ก๐๐ง๐ ๐ ๐๐ง๐ง๐๐ฅ๐ฆ For men 35+, resistance training deserves particular attention. A systematic review and meta-analysis found that muscle-strengthening activity was associated with lower risks of all-cause mortality, cardiovascular disease, cancer and diabetes. The analysis found associations with roughly 10โ17% lower risk across several major outcomes. Another meta-analysis found resistance training was associated with lower all-cause mortality, with additional benefit when combined with aerobic exercise. ๐ง๐๐๐ก๐ ๐๐ก ๐๐๐ฃ๐๐๐๐ง๐ฌ, ๐ก๐ข๐ง ๐๐จ๐ฆ๐ง ๐๐๐๐ข๐ฅ๐๐๐ฆ Exercise isn't simply about burning calories. It helps maintain muscle, strength, cardiovascular fitness and physical independence. Those become increasingly valuable as the decades accumulate. ๐ง๐๐ ๐ ๐๐ก๐ฏ๐ฑ ๐๐ฅ๐๐ ๐๐ช๐ข๐ฅ๐ You don't need to train like an athlete. A sensible foundation is: Resistance training to preserve muscle and strength. Aerobic activity to maintain cardiovascular fitness. Daily movement to avoid turning the rest of the day sedentary. Consistency matters more than chasing the perfect program. ๐ ๐๐ก๐ฏ๐ฑ ๐ง๐๐๐๐๐ช๐๐ฌ The future of longevity medicine may be extraordinary. But you don't need to wait for it. Build the biological foundation now. ๐ง๐๐ ๐๐ข๐ง๐ง๐ข๐ ๐๐๐ก๐ For men over 35, exercise remains one of the most evidence-backed investments in long-term health. Move better. Stay strong. Keep going.
David A. Sinclair, A.O., Ph.D.
Professor of Genetics, Harvard Medical School ยท Aging biology, NAD+ metabolism, epigenetics and longevity
For informational purposes only. This is not medical advice โ consult a doctor before changing medication, supplements or training.