Longevity · Expert

NAD+ AND LONGEVITY: WHAT WE KNOW

The Diary of a CEO with Steven Bartlett · 17/09/2026 · added by men35 desk

NAD+ is central to energy metabolism and cellular repair, making it one of longevity science’s most discussed molecules. But raising NAD+ is not the same as reversing aging. 𝗞𝗘𝗬 𝗕𝗘𝗡𝗘𝗙𝗜𝗧𝗦 Explains what NAD+ actually does Connects NAD+ with sirtuins and cellular metabolism Reviews human NMN and NR trials Separates biomarker changes from proven longevity benefits 𝗪𝗛𝗔𝗧 𝗜𝗦 𝗡𝗔𝗗+? Nicotinamide adenine dinucleotide, or NAD+, is a molecule involved in energy metabolism and several cellular processes. It also acts as a cofactor for enzymes involved in processes including DNA repair and regulation of gene expression. NAD+ levels tend to change with age, which has made NAD-boosting strategies a major area of longevity research. 𝗧𝗛𝗘 𝗛𝗨𝗠𝗔𝗡 𝗗𝗔𝗧𝗔 𝗜𝗦 𝗜𝗡𝗧𝗘𝗥𝗘𝗦𝗧𝗜𝗡𝗚 In a randomized trial of 30 overweight or obese adults aged 45+, NMN substantially increased circulating NAD and its metabolites. The study also observed reductions in body weight, LDL cholesterol and diastolic blood pressure. But it was small and lasted only 28 days, and measures of muscle performance and aerobic capacity did not significantly improve. A separate 2024 randomized trial involving 60 older adults found that NMN increased blood NAD+ levels, but the primary stepping-test outcome did not significantly differ from placebo. 𝗧𝗛𝗘 𝗞𝗘𝗬 𝗗𝗜𝗦𝗧𝗜𝗡𝗖𝗧𝗜𝗢𝗡 Increasing NAD+ is measurable. Whether doing so meaningfully slows human aging is still an open research question. That distinction is critical when evaluating supplements. 𝗠𝗘𝗡𝟯𝟱 𝗧𝗔𝗞𝗘𝗔𝗪𝗔𝗬 NAD+ is real biology—not marketing fiction. But a higher NAD+ blood level should not automatically be translated into “younger.” 𝗧𝗛𝗘 𝗕𝗢𝗧𝗧𝗢𝗠 𝗟𝗜𝗡𝗘 NAD+ boosters are scientifically interesting. They are not yet proven anti-aging treatments.

For informational purposes only. This is not medical advice — consult a doctor before changing medication, supplements or training.